Brief summaries of the video clips throughout the course may be accessed through the links below. All are pdf files.
Week 1
Chapter 1 - Early Drugs
- Clip 1 - Ephedrine
- Clip 2 - Sulfa Drugs
- Clip 3 - Elixir Sulfanilamide Tragedy
Chapter 2 - Drug Discovery: From Concept to Market
- Clip 1 - Drug Discovery Outline
- Clip 2 - Phenotype vs. Target
- Clip 3 - Patents and Branding
Week 2
Chapter 3 - Protein Structure
Chapter 4 - Enzymes
- Clip 1 - Theory of Action
- Clip 2 - Reversible Inhibitors
- Clip 3 - IC50 and Ki
Chapter 5 - Receptors
- Clip 1 - Receptor Superfamilies
- Clip 2 - Ligand Types
- Clip 3 - The Pros and Cons of the Clark Model
Week 3
Chapter 6 - Blood and Drug Transport
- Clip 1 - What Is Blood?
- Clip 2 - ADME
Chapter 7 - Pharmacokinetics
- Clip 1 - Cp vs. time
- Clip 2 - Clearance Demonstration
- Clip 3 - Area Under Curve
- Clip 4 - One-Compartment Model
- Clip 5 - Two-Compartment Model
- Clip 6 - Bioavailability
Week 4
- Clip 7 - Multiple Oral Doses
- Clip 8 - CL vs. Vd plots
Chapter 8 - Metabolism
- Clip 1 - Metabolism and Vd
- Clip 2 - Phase I - Oxidation
- Clip 3 - Phase I - Reduction and Hydrolysis
- Clip 4 - Phase II - Conjugation
- Clip 5 - CYP Inhibition and Genetics
- Clip 6 - Prodrugs
Week 5
Chapter 9 - Binding, Structure, and Diversity
- Clip 1 - Binding Energy
- Clip 2 - Stromelysin
- Clip 3 - Pharmacophores Revisited
- Clip 4 - Numbers Game
- Clip 5 - Molecule Collections
- Clip 6 - Combinatorial Chemistry
Week 6
Chapter 10 - Lead Discovery
- Clip 1 - Finding Hits
- Clip 2 - Fragment Based Screening
- Clip 3 - Visual Inspection
- Clip 4 - Molecular Indexes
- Clip 5 - Other Lead Selection Criteria
- Clip 6 - SOSA
- Clip 7 - Natural Products
Week 7
Chapter 11 - Lead Optimization
- Clip 1 - Feedback Cycle
- Clip 2 - Structure-Activity Relationships
- Clip 3 - Homologous Series
- Clip 4 - PK-Focused Changes
- Clip 5 - Covering All Possibilities
- Clip 6 - Peptides As Hits and Leads